NCA, Bioequivalence, Food-Effect and Dose-Proportionality
reports — the standard regulatory PK analyses, generated
automatically from a CSV. Plus three advanced engines
(Population PK, Tumor Growth, Drug Release) for cases where
classical exponential models miss the picture. Non-regulated
reports, automatic verdict, PDF in your inbox.
Demo mode: the seven sample reports below use
synthetic demonstration datasets labelled as such in every PDF.
The NCA engine is validated against PKNCA 0.12.1 on the public
reference theophylline dataset — see
Algorithm Validation.
Uploading your own data requires an approved account.
Live sample · NCA report
FractaLPK Engine
Observed concentration
Population mean ± SD
Time →
Concentration ↑
NCA — Population summary
Cmax, AUC0-t, AUC0-∞, λz, t½
Validated
PKNCA-alignedQuality flags per subjectRegulatory disclaimer
Validated against PKNCA 0.12.1 on the reference theophylline
dataset — agreement within 0.15 % on AUC-class parameters,
bit-identical Cmax/Tmax.
Start with the live samples; request an account when you're ready to upload your own data.
Step 1
Explore the samples
Seven engines, seven synthetic demonstration datasets (labelled as such in every PDF). Open each one to see the verdict, models compared and diagnostic plots — exactly the report a paying client receives.
Step 2
Request access
Tell us your name, company and what you're trying to analyse. We reply within one business day with an upload link and a single-use checkout (€299 per report).
Step 3
Upload & receive
Upload your CSV, get a magic-link to the PDF when the fit completes (typically 5–10 minutes), and a copy in your inbox. No subscription, no commitment.
Live samples — open the PDFs
Each PDF is generated by the same engine that processes paid uploads. Same plots,
same verdict logic, same regulatory disclaimer.
The first four are the standard regulatory PK reports.
The last three are the advanced fractional engines — see
Advanced engines below.
Algorithm Validation
The NCA engine is cross-validated against PKNCA, the de-facto open-source standard for non-compartmental analysis.
NCA engine validated against PKNCA 0.12.1 on the public reference theophylline dataset (12 subjects, single oral dose). Agreement is within
0.15 % on AUC-class parameters and
bit-identical on Cmax and Tmax across every subject.
Pinned versions, full method-alignment table and per-subject diff are in the report.
Scope: this validation covers the NCA engine specifically. Bioequivalence, Food-Effect and Dose-Proportionality wrap the same NCA core. The advanced fractional engines (PopPK, Tumor, Drug Release) are non-regulated screening tools and are not subject to this cross-validation.
Built for early-stage screening, when you need a fast answer before opening a full regulatory analysis.
Fractional models
Detect memory effects and long tails that classical exponential models flatten out — common in fractured tablets, heterogeneous tissue and saturating tumour growth.
Multi-model verdict
Up to 8 candidate models fitted in parallel. The engine ranks them and applies an explicit decision rule — no manual model-selection bias.
Automatic diagnostics
Stability check, residuals and "Best fit" badge in every report. If no model wins clearly, the PDF says so — no false-positive verdicts.
Built for screening
Non-regulated, designed to sit before NONMEM / Monolix / PKanalix. Good for biotech early-stage, CROs running internal triage, and academic exploration.
Why not just use R + PsN?
The R / Quarto / bbr / pmtables / Xpose / PsN stack is free and excellent. It is also the right answer for some teams. This section explains when FractaLPK adds value and when it does not.
Zero R, zero NONMEM
Upload a CSV, receive a regulatory-format PDF. The R stack assumes you already have a NONMEM / nlmixr2 run and know how to write Quarto templates, pmtables headers and Xpose plotting code.
Automatic verdict + quality flags
Every per-subject NCA row carries NTP / HIE / EXE / SPI flags with the engine's interpretation. pmtables / bbr give you tables, not decisions — you still own the call.
Fractional kinetics built-in
Detects long memory effects classical exponential ODEs miss. The R PK ecosystem assumes the model class is given; FractaLPK selects from 8 candidates and tells you when none of them wins clearly.
Minutes, not days of setup
Time from CSV upload to PDF in your inbox is 5–10 min. Standing up an R / Quarto / PsN pipeline that produces the same artefact takes a senior pharmacometrician days to weeks.
When FractaLPK is NOT for you: if you have an in-house pharmacometrics team already running PsN / bbr / pmtables, FractaLPK does not replace that workflow — your team's R pipeline is the right tool. FractaLPK is built for biotechs, CROs and academic groups that need a fast PK answer before opening a full regulatory analysis.
The standard NCA / BE / FE / DP reports cover the regulatory baseline. The three advanced engines below are for cases where classical exponential ODEs visibly miss the data.
Population PK
Multi-compartment + fractional / Mittag-Leffler PK fits with explicit model-selection rule. For profiles where the terminal phase is heavier than a sum of exponentials predicts.
These three engines are research / screening tools; they are NOT cross-validated against PKNCA or any other regulatory reference. The "Best fit" verdict and fractional-model selection are FractaLPK's own decision rules, designed for early triage, not regulatory submission.
Pricing
Pay-per-report. No subscription. No card on file. Cancel = stop sending CSVs.
Sample access
Free · no signup
Public · open right now
Open the seven sample PDFs (PopPK, Tumor, Drug Release, NCA, Bioequivalence, Food Effect, Dose Proportionality).